This guide walks readers through the process of thinking about policy and practice changes from an anti-racism, HOPE-informed lens. The resource provides case studies in early childhood education and pediatrics to guide readers through the process of reviewing the data, engaging their communities, and making change — giving concrete examples of how to use HOPE and anti-racism to effect systemic change. Thank you to Dr. Baraka Floyd for developing this guide, and thank you to Amanda Winn for facilitating the guide’s creation!